Low Osmolar Contrast Media (LOCM)
-Non-dissociating.
-Only about 2x serum osmolality.
-Less side effects, less nephrotoxic.
E.g. Ultravist, Omnipaque
Iso-osmolar Contrast Media
-Osmolality approximately serum osmolality.
-Preferred in renal impaired patients.
E.g. Visipaque
Oily Contrast Media
-Currently not widely used
-Used for – chemoembolisation
E.g. Lipiodol Ultra Fluid
METHODS OF ADMINISTRATION:
A)Intravenous injection
1. Highlight blood vessels.
2. Enhance structure of organs.
3. Rapidly eliminated by kidneys.
B) Oral administration
C)Rectal administration
For Oral and rectal–>
1. Highlight gastrointestinal tract in the abdomen and pelvis.
2. Positive contrast – iodinated CM(Gastrografin)
3. Negative contrast
– water
– air (CT colonoscopy)
D)Intrathecal injection
E)Intra-articular injection
CONTRAINDICATIONS
Recognizing patients at risk of contrast media reaction
1.Proven/suspected hypersensitivity to iodine
2.Previous severe reaction to contrast media
3.Asthma/significant allergy history
4.Heart disease
5.Infants/children/elderly
6.Liver failure
7.Renal impairment (moderate-severe) – NIDDM on Metformin
8.Myelomatosis
9.Poor hydration
10.Sickle cell anaemia
11.Thyrotoxicosis
12.Pregnancy
13.Phaeochromocytoma
IN THESE GROUPS OF PATIENTS, LOCM SHOULD ALWAYS BE THE CHOICE OVER HOCM!!
Overall incidence of contrast media reactions
HOCM: 5-12%
LOCM: 1-3%
Mortality rates of contrast media reactions
HOCM: approx 1:40,000
LOCM: approx 1: 200,000
Types of Contrast Media Reactions
1. Anaphylactoid (idiosyncratic)
Urticaria, facial & laryngeal oedema, bronchspasm, hypotension – life threatening
2. Non-idiosyncratic
Direct effect on organs (nephrotoxicity, vasovagal attacks, arrythmias, MI)
3. Local reaction
Extravasation, phlebitis
Severity of Contrast Media Reactions
Mild: Hives, flushed feeling, metallic taste, nausea, vomiting
Moderate: Bronchospasm, laryngospasm, hypotension
Severe: Life threatening anaphylaxis
!! REACTION MAY BE DELAYED UP TO 1 WEEK !!
PATIENT PREPARATION
- Fasting 4-6 hrs
- Steroid cover – allergy, asthma
- T. prednisolone 50 mg 13, 7, 1 hr before examination
- IV hydrocortisone 200mg stat
3. Renal impairment
- N-acetyl cysteine 600mg the day before and 1 day after examination





MR CONTRAST AGENTS
Paramagnetic / Superparamagnetic
-Causes changes in the local magnetic field
–>shortened T1 relaxation time – increases signal intensity on T1-weighted images
–>shortened T2 relaxation time – decreases signal intensity on T2-weighted images
e.g.Gadolinium-DTPA (Magnevist)
Newer MRI contrast media
1.Liver-specific MRI agents
-Accumulates in the liver
e.g. Resovist, Primovist, MultiHance
2.USPIO (ultrasmall paramagnetic iron peroxide particles)
-Accumulate in macrophages in lymph nodes
-Currently undergoing clinical trials, no FDA approval as yet
COMPLICATIONS
1.Hypersensitivity reaction
2.Nephrogenic systemic fibrosis
-Recently reported serious late adverse reaction of gadolinium-based contrast.
-Seen in patients with renal failure and on dialysis.
-Fibrosis of skin and organs.
-Clinical symptoms developed 2-8 weeks after exposure to gadodiamide.
-Avoid in patient with creatinine clearance <15mL/min.

Source :
Dept of Biomedical Imaging UMMC
CT and MRI for non-radiologist Course
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